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Description

While GAs are unified by their capacity to induce common physiological end-points, there is a significant heterogeneity among individual agents, in both their chemical composition and specific molecular (off) targets (33)

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In PTC and ATC cell lines, aurora-A, a member of the aurora serine/threonine kinase family, induces glycolysis by activating 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), and the inhibition of aurora-A with its selective inhibitor, alisertib, has been shown to improve the efficacy of sorafenib in both PTC and ATC cells [77]